Nolomirole hydrochloride form i

Nolomirole chlorhydrate de forme i


Nolomirole hydrochloride in a highly purified crystalline polymorphic form I, the process for its preparation and pharmaceutical preparations thereof for the treatment of patients suffering of cardiovascular diseases such as congestive heart failure are described.
L'invention concerne du nolomirole chlorhydrate dans une Forme I polymorphe cristalline à pureté élevée, son procédé de préparation et ses préparations pharmaceutiques destinées au traitement de patients souffrant de maladies cardio-vasculaires telles que les insuffisances cardiaques globales.




Download Full PDF Version (Non-Commercial Use)

Patent Citations (3)

    Publication numberPublication dateAssigneeTitle
    GB-2123410-AFebruary 01, 1984Chiesi Farma SpaNew derivatives of 1,2,3,4-tetrahydronaphthalene, process for their preparation and associated pharmaceutical compositions
    WO-0185668-A1November 15, 2001Chiesi Farmaceutici S.P.A.Derives de 2-aminotetraline optiquement actifs, leurs procedes de preparations et l'utilisation therapeutique de compositions pharmaceutiques les contenant
    WO-9629065-A2September 26, 1996Chiesi Farmaceutici S.P.A.Derive d'aminotetraline pour la therapie des maladies cardio-vasculaires

NO-Patent Citations (3)

    GIORDANO, FERDINANDO ET AL: "Polymorphism of rac-5,6-diisobutyryloxy-2-methylamino-1,2,3,4-tetrahydro- naphthalene hydrochloride ( CHF 1035 ). I. Thermal, spectroscopic, and X-ray diffraction properties", JOURNAL OF PHARMACEUTICAL SCIENCES (2001), 90(8), 1154-1163, XP002223546
    MEALY, N. E. ET AL: "Nolomirole hydrochloride: treatment of heart failure dopamine D2 agonist.alpha.2-adrenoreceptor agonist CHF - 1035", DRUGS OF THE FUTURE (2001), 26(11), 1046-1051, XP009002202
    TADDEI, PAOLA ET AL: "Vibrational study of polymorphism of tetralin derivative for treatment of cardiovascular diseases", BIOPOLYMERS (2002), VOLUME DATE 2001-2002, 61(3), 289-293, XP009002199

Cited By (1)

    Publication numberPublication dateAssigneeTitle
    WO-2017110317-A1June 29, 2017昭和電工株式会社Nicotinamide mononucleotide derivative, salt thereof, production method therefor, dermatological topical agent, cosmetic, and food additive