New derivatives of 1,2,3,4-tetrahydronaphthalene, process for their preparation and associated pharmaceutical compositions

Abstract

1,2,3,4-tetrahydronaphthalenes are described having the formula: <IMAGE> where R represents hydrogen, C1-C4 alkyl, cycloalkyl containing from 4 to 7 carbon atoms or arylalkyl of the type <IMAGE> where R1 and R2, which may or may not be the same, represent hydrogen or C1-C4 alkyl; n = 1 or 2; Ph represents a phenyl radical possibly having one or more atoms of halogen or hydroxy or methoxy groups or a methylenedioxy group; Z and Z1, which may or may not be the same, represent hydrogen, C1-C4 alkyl, cycloalkyl containing from 3 to 7 atoms of carbon or an -AR3 radical in which A represents a -CO- or -SO2- group and R3 a linear or branched chain alkyl having from 1 to 15 atoms of carbon or a phenyl possibly substituted by a C1-C4 alkyl; and their addition salts with pharmaceutically acceptable inorganic or organic acids. These compounds have a sympathomimetic activity.

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