Verfahren zur Herstellung der Form I von Nolomirol Hydrochlorid

Procédé de fabrication de la forme I de l'hydrochlorure de nolomirol

Process for the manufacture of form I of nolomirole hydrochloride

Abstract

A process for the preparation and isolation of the pharmaceutical chemical compound nolomirole hydrochloride in a highly purified crystalline Form I, as well as pharmaceutical preparations thereof for the treatment of patients suffering of cardiovascular diseases such as congestive heart failure and hypertension are described.

Claims

Description

Topics

Download Full PDF Version (Non-Commercial Use)

Patent Citations (3)

    Publication numberPublication dateAssigneeTitle
    GB-2123410-AFebruary 01, 1984Chiesi Farma SpaNew derivatives of 1,2,3,4-tetrahydronaphthalene, process for their preparation and associated pharmaceutical compositions
    WO-0185668-A1November 15, 2001Chiesi Farmaceutici S.P.A.Derives de 2-aminotetraline optiquement actifs, leurs procedes de preparations et l'utilisation therapeutique de compositions pharmaceutiques les contenant
    WO-9629065-A2September 26, 1996Chiesi Farmaceutici S.P.A.Derive d'aminotetraline pour la therapie des maladies cardio-vasculaires

NO-Patent Citations (3)

    Title
    GIORDANO, FERDINANDO ET AL: "Polymorphism of rac-5,6-diisobutyryloxy-2-methylamino-1,2,3,4-tetrahydro- naphthalene hydrochloride ( CHF 1035 ). I. Thermal, spectroscopic, and X-ray diffraction properties", JOURNAL OF PHARMACEUTICAL SCIENCES (2001), 90(8), 1154-1163, XP002223546
    MEALY, N. E. ET AL: "Nolomirole hydrochloride: treatment of heart failure dopamine D2 agonist.alpha.2-adrenoreceptor agonist CHF - 1035", DRUGS OF THE FUTURE (2001), 26(11), 1046-1051, XP009002202
    TADDEI, PAOLA ET AL: "Vibrational study of polymorphism of tetralin derivative for treatment of cardiovascular diseases", BIOPOLYMERS (2002), VOLUME DATE 2001-2002, 61(3), 289-293, XP009002199

Cited By (0)

    Publication numberPublication dateAssigneeTitle